Cart Search


J J   06 Dec 2019

Cissus Quadrangularis Health Benefits


What is Cissus Quadrangularis?

Cissus Quadrangularis is a plant taken for its health benefits, with some records dating back to thousands of years. It’s a plant that belongs to the grape family, which explains why it’s also called veldt grape. The plant is also native to Asia, Africa, and some parts in the Arabian Peninsula. 

Some Cissus Quadrangularis health benefits and usage include treatment for conditions such as hemorrhoids, asthma, allergies, and gout. Its healing properties are greatly attributed to its high vitamin C and antioxidant content. Recently, science has also confirmed the potential Cissus Quadrangularis benefits for bone health, joint pain, inflammation, diabetes, strokes, and even heart disease.

Today, you may take advantage of Cissus Quadrangularis benefits by purchasing it as an herbal supplement. What can you get if you take Cissus Quadrangularis supplements?


Cissus Quadrangularis Benefits for Health and Performance

1. Symptoms of Obesity

Obesity is linked to complications involving blood pressure, blood cholesterol content, and increased risk of heart disease. Cissus Quadrangularis has been cited for its positive effects on conditions related to obesity and explains why some heart-healthy supplements are now including Cissus Quadrangularis in their formulas. 

To test the Cissus Quadrangularis benefits on obesity and its related symptoms, researchers asked overweight volunteers aged 19 to 50 years old to partake in an experiment with placebo and a supplement that uses Cissus Quadrangularis as the main ingredient. 

The results of the experiment were conclusive on the benefits of Cissus Quadrangularis for weight loss, lower blood cholesterol and triglycerides, blood sugar, and blood pressure. [1]

2. Diabetes

Many researchers agree that diabetes is often the result of both obesity and chronic insulin resistance – a condition when the body’s insulin is no longer able to remove sugar from the blood circulation efficiently. While a person can control their food intake, some who have been diabetic for years will likely be dependent on insulin injections just to help lower blood sugar levels. 

Animal studies show the potential benefits of taking Cissus Quadrangularis on lowering blood sugar. Researchers attribute this property to the herb’s high antioxidant activity, which lowered oxidative stress which then helped elevate insulin sensitivity to functioning levels. In the same study, researchers also noted Cissus Quadrangularis benefits on liver health. [2]

3. Joint pain

One of the more popular reasons to take Cissus Quadrangularis supplements is for joint pains, especially when it comes to arthritis. Joint pains are considered inflammatory conditions, and the inherent anti-inflammatory property of Cissus Quadrangularis helps in neutralizing inflammation. 

In one study concerning 29-men with chronic joint pain, it was found that a daily dose of 3,200 mg Cissus Quadrangularis helped reduce joint-swelling which therefore lead to reduced pain. [3]

4. Bone health

Osteoporosis is a disease that reduces the quality and density of bones. The more porous and fragile bones are, the higher the risks of fractures and injuries. Cissus Quadrangularis may help with reducing bone loss, improve fracture healing rate, and even prevent osteoporosis. 

In one study, researchers showed taking 500 mg of Cissus Quadrangularis three times a day for six weeks significantly improved fractured jaw bone healing rate. It also helped lower swelling and pain. [4]

5. Inflammation

Many experts agree that chronic inflammation is one of the primary causes of almost every disease known to man. Some of the diseases that are rooted in chronic inflammation are heart disease, rheumatoid arthritis, type 2 diabetes, asthma, Alzheimer’s disease, and cancer.

Many studies have demonstrated the anti-inflammatory benefits of taking Cissus Quadrangularis, especially in experiments involving joint pain and hemorrhoids. [5]



Cissus Quadrangularis is a plant that has been used for its therapeutic benefits for thousands of years. Recent studies demonstrate its ability to relieve pain and joint swelling, mitigate inflammation and risks of inflammatory diseases, promote bone health, manage type 2 diabetes, and reduce markers associated with heart disease and obesity. Because of the solid evidence surrounding the many Cissus Quadrangularis benefits, supplement companies have been including this all-in-one herb in many wellness formulas. 

Cissus Quadrangularis is available in powder form. 



  1. Oben JE, Enyegue DM, Fomekong GI, Soukontoua YB, Agbor GA. The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress. Lipids Health Dis. 2007;6:4. Published 2007 Feb 4. doi:10.1186/1476-511X-6-4
  2. Lekshmi RK, Divya BT, Mini S. Cissus quadrangularis extract attenuates hyperglycaemia-mediated oxidative stress in streptozotocin-induced diabetic rats. Redox Rep. 2014;19(5):214-20.
  3. Bloomer RJ, Farney TM, Mccarthy CG, Lee SR. Cissus quadrangularis reduces joint pain in exercise-trained men: a pilot study. Phys Sportsmed. 2013;41(3):29-35.
  4. Brahmkshatriya HR, Shah KA, Ananthkumar GB, Brahmkshatriya MH. Clinical evaluation of Cissus quadrangularis as osteogenic agent in maxillofacial fracture: A pilot study. Ayu. 2015;36(2):169–173. doi:10.4103/0974-8520.175542
  5. Shadmani A, Rizwani GH, Ahmed M. Potential anti-inflammatory effect of Cissus quadrangularis L. and Lepedium sativum L. along with their combination extracts. Pak J Pharm Sci. 2018;31(5(Supplementary)):2119-2122.


CYOS blog content is for informational and educational purposes only, and should not be considered medical advice, diagnosis or treatment recommendations. Always consult with your doctor or medical professional before using any dietary supplements or if you suspect you have any medical concerns or issues.




100% Pure • Encapsulated in Australia • Vegetarian Capsules • No Fillers • No Additives • No Binders • No Anti Caking Agents • Allergen Free • No Preservatives • Non GMO

Shop now

Our best sellers

  • Storage Containers


    Full details
  • TMG Trimethylglycine Powder (Betaine Anhydrous)

    SKU: TMGp

    Full details
  • NAC (N-Acetyl L-Cysteine) Capsules

    SKU: NACc

    Full details
  • N-Acetyl L-Cysteine (NAC) Powder

    SKU: NACp

    Full details
This error message is only visible to WordPress admins

Error: API requests are being delayed. New posts will not be retrieved for at least 5 minutes.